It depends on what channel, amount of gain, how the tone controls are set, your guitar and pickups, tubes, speaker and cabs you use. ..... and most important what sound you are going for.
If you are trying to get a Plexi type sound. Turn the master in the 11 ~ 5 o'clock range and turn up the mids. The clean channel get the pretty close to this sound. But you can get other voices from the other channels.
The cleans can be set with a very very low gain with the master just about dime for a great Fender twin like feel.
The lead sounds on the Orange channel well sound good up to about 2.
Metal I like the red channel up to about 11 for my taste.
I use a THD Hot Plate so I can do this and control the volume.
You well hear the sweet spot when you hit it.