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I'm just running mono, so can't offer much or any insight about your stereo rig. For me, it just boils down the carry factor. I run a Mark III combo on top of a 1x12 recto most times--it's fine and sure gets the job done. But if my bro' and I are riding together and we take his van, I use a 2x12 vertical under the combo. Honestly, the 2x12 just kills the little 1x12 in every way. Taking a preemptive Naproxen can usually help with my old-age limitations...