I run mine with the center pair pulled out, half of the fuse value (from a 4 amp down to 2 amp, I think?). I could have also pulled one of the rectifier tubes, but I like the way it sounds running two, it feels a little tighter. I went down on the impedance from the 8 ohm speaker out to one of the 4 ohm outs for my 8 ohm cab. I was running it at 8 for a while, but then some one here told me that I needed to do this to match the output transformer to the power tube removal. I found that this opened the tone up almost dramatically.
I run it this way @ 50 watts because it gives me a little more manageability at the volume I run at without burning up the extra pair of valvesI don't really need. But it's really nice to have the choice to go back up to a hundred watts when I want the extra head room. As far as I know this doesn't hurt the amp in any way ...
If anyone out there knows something about this that I may be missing, I'd really like to hear it.