I have done this. It sounded good, but I was running into volume problems with my other guitar player. I was using my 4x12 and the extra 4x12 that sits next to it so needless to day I was dominating. From my brief experiment with this, I found that running clean on the lonestar and a little dirty on CH3 of my roadster sounded nice. If I had 2 2x12 cabs, or I rewired my 4x12 it would definitely do more of this.