For my main lead sound, I use Channel 3 Vintage, 2x6L6s, Tube rectifiers. Gain = 2:30/3:00, Treble = 11:00/11:30, Mid = 10:30/11:00, Bass = 9:30/10:00, Presence = 12:00/12:30. This works best with my Ibanez S540LTD with DiMarzio Steve's Special in the bridge. Initially, I had the Mids dialed in at around 2:00. That mid setting gave the guitar a stiffer feel. After reading the manual, I rolled the mids down some. Rolling the mids down did not thin out the tone, but, it made playing leads feel more "fluid".
(BTW, I have a JAN Phillips 12AX7 in V1, Tung Sol RI 12AX7s in V2 & 3, finally, I have a JJ Balanced 12AX7 in V6 (phase inverter), so, YMMV)