Standing in front of the amp will give you the most harshness, yeah. That's normal. It's because the high-frequencies that normally die off before they reach your ears when you are standing away to the side are now blasting directly at you.
Also, I forgot to mention before: low frequencies have a large area of effect, and become more and more uni-directional the lower they go. This is why bass can be heard everywhere, and is felt as "omni-present". Loud bass is hard to source, because it just feels like it is enveloping the entire room, which isn't far from the truth. High-frequencies operate in the opposite way... the higher they go, the more focused they are. The highest over-tones and harmonics that your amp produces will only be heard if you are right in front of your amp. Some see this as harshness, which it can be if your presence is too high, but a good balance is generally considered to be pleasing and part of the package.
A little background info: when you hit your string, the string will produce the fundamental tone (which is the note you hit), as well as a whole series of notes above it called the natural harmonic series. As the series goes higher and higher, the volume slowly dies down, so in effect the overtones close to the fundamental are louder and the overtones way high up are barely audible. When you amp your guitar, the amp picks up all these little guys and raises the volume by many, many, many times. It also raises the fundamental too, which will become compressed beyond a certain point. If you crank the volume even further, then the entire harmonic spectrum will become compressed into a mush of ****, which is why sometimes turning your amp up too loud is a bad idea, because you lose all clarity and harmonic "relativeness", so to speak, and everything just sounds like a jar of noise.
EDIT: Cranking the volume and compressing the sound like this is sometimes desirable for lead sounds, where you want a nice, thick, creamy lead sound (read: a ****-load of harmonic overtones that are almost as loud or as loud as the fundamental tone). But for rhythm or anything involving more than 1 or 2 notes at a time, it's usually a bad idea, because you will lose clarity like I said, and tonality and chord-voicings can be lost in this.
Anyway, what I'm trying to get at is this: lower your presence, try it at around 12 or 1o'clock. Also, know that treble and presence are linked. If you don't want your presence that low, lower the treble. Also remember that lowering the treble will allow more bass & mids back into the mix, so you will have to adjust there.