I've found that the modulations (specifically the phaser and flanger) can really be tailored to your liking. I could always get the sound I was looking for out of them (still, as I said, I've always been a fan of the TC sound). I find that, for cleans, the modulations really work well in the loop. However, for higher gain, I think I'd like the chorus a bit more if I could place it in front of the amp. Still, after some tweaking, I've found a sound I'm really pleased with. Having said this, when I add chorus to a high gain sound I mainly use it for passages where I'm arpeggiating chords with odd voicings/intervals, so that it makes everything a bit more clear, to help you pick out the individual notes, so it's not such a dramatic chorus.
I forgot to mention, Fractal also came out with a multi effects processor which can be connected using the 4CM, so that you can place any effect wherever you want in the signal chain. Of course you also have the alternative of picking up a used Axe FX standard and a MIDI foot controller (you can find them relatively cheap these days if you look enough and have a bit of luck). Still the Nova System is unbeatable for the price point it's at. Honestly, my only problem with it is the really long cable run (which half of it is well funded with a sonic reason and half of it is OCD really).