OK, call Mesa's customer support for sure. I'm sure they can help. I have an Electra Dyne long head with matching 1 x 12 head and I have not had that problem.
That being said, it sounds like a preamp tube problem.
**Ideas**
The gain trim switch changes the amount of gain / clean headroom between the clean mode and vintage lo / hi.
If you want more gain on Vintage Lo Hi with more clean headroom, you select clean. If you want to overdrive the clean mode and have a less saturated tone on vintage hi then you select low hi. Normal is the happy medium with the most balanced tone between modes.
SO, you are hearing the hum on vintage lo / hi? I'd suggest looking at the preamp tubes, especially v1 and v2. Look at the tube task chart and determine which tubes are driving vintage lo and hi.