The 2:Ninety is a stereo power amp. Think of it as two separate tube power amps.
Each side needs a load resistor (speaker).
You're fine if you have two cabs or one that can be used in stereo.
Hook up side A to one cab and side B to another.
If you only have one cab or a cab that can't be used in stereo, you'll need to turn the volume and presence down for the channel not in use.
If a tube amp is taken off of standby without a way to get rid of it's energy.. you can blow tubes or worst (power transformer).
I don't know that I'd even take the chance with having a channel set to zero. I will say that I have run into an issue where a speaker cable wasn't plugged in all of the way.
Once I realized it.. I put the amp on standby and secured the connections. Luckily everything was fine.
Brian