with my MV:35 I have done both - when I first got the amp it was my first amp w/a loop so I got all the cables necessary to do the 4-cord thing and it sounded fine - a chorus or trem or vibe or verb effect with the guitar - cool. Then I began to get tired of fussing with all the long cable runs on stage from the pedal board back to the amp for the loop so I went back to my old school "everything through the front of the amp" way (the way Leo intended) with just one line-out cord feed from the whole pedal board - with this system all the modulation pedals are after the Wah (which is first after the tuner) and OD's, so the final line of pedals are: Chorus, Trem (and a vibe if I need it for the set list), and finally Delay. Either way I always used just a touch of the MV:35 built-in Reverb for each channel. That way sounded just as good. The live recordings of the band confirmed it sounded great too, and the on-stage spaghetti was drastically reduced, set up simplified and all. Also note: I'm in a Classic R&B/Soul/Funk/Blues Rock, 9 piece band so my effect needs are very fundamental - so take this info with that in mind. For large Ambient long-tail reverb layered-up environmental playing, the loop is probably the best way to go. Most of the time I only need a little slapback delay and no reverb if the room is big enough. So try it either way and go with whatever sounds good to you.