Have you modded the Bias? If not, you probably have a component failing. If you have, read on!
With the chassis out, check across any Power tube pin 3 (+) to ground (-) with your meter on DCV. That will give you the Plate voltage. Then divide the tube's maximum wattage (Power) rating by that voltage reading. Let's say you read 380V at pin 3. 25/380 = .066. You then multiply that answer by .7. .066*.7 = .046. That (.046) is what you should set your bias to.
(WATTS/PLATE VOLTAGE)*.7 = Bias Voltage