I'm using an Alesis Quadraverb in the effects loop, it has a graphic eq, I raised the 62, 126 and lowered the 250.
I mainly use the tite gain mode, with presence at 10 o'clock, bass at two o-clock, mid at 11 o'oclock, treble at 11 o'clock, gain almost all the way up, master volume at 1 o'clock...