Here s a copy of my post from another thread:
I just got a Line 6 M13 Stomp Box Modeler (SIICK!) and I run the 4 Cable method...
With the M13 you can assign 1,2,3 or all 4 FX banks to run in front of or in it's loop so...
I run the 1st 2 banks of FX in FRONT of the amp (OD's and Filters) and...